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EFFECT OF
CAFFEINE ON BLOOD GLUCOSE AND LIPID PROFILE IN ALLOXAN-INDUCED DIABETIC WISTAR
RATS
Abstract
Diabetes
mellitus is characterized by hyperglycemia. Caffeine has been suggested to be
capable of disrupting glucose metabolism. The effects of caffeine on blood
glucose level and on lipid profile of alloxan induced diabetic Wistar rats were
studied. The effect of caffeine by determining the blood glucose levels at
intervals of 30mins, 1hour and 2hours respectively following administration of
caffeine. Caffeine at a dose of 25 mg/kg and 100 mg/kg produced significant
(P<0 .05="" 0.05="" 100="" 25mg=""
2="" a="" administration="" after=""
all="" although="" and="" animal=""
animals.="" animals="" at="" be=""
blood="" body="" caffeine="" can=""
causes="" changes="" compared=""
comparison="" concluded="" control.=""
control="" dependent.="" diabetic=""
difference="" dose="" duration=""
experiment="" found="" glucose="" group.=""
groups.="" groups="" hours="" in=""
increase="" increases="" indices=""
it="" kg="" lasted="" level=""
levels="" lipid="" may="" mg=""
no="" of="" on="" other=""
produce="" profile="" rats.="" rats=""
received="" results="" showed="" significant=""
significantly="" span="" suggest=""
that="" the="" there="" therefore=""
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CHAPTER ONE
1.0 INTRODUCTION
1.1 Diabetes Mellitus
Excessive
urine excretion is one of the major symptoms of diabetes. The most common form
of diabetes is diabetes mellitus, a metabolic disorder in which there is an
inability to oxidize carbohydrate due to disturbances in insulin function.
Diabetes mellitus is characterized by elevated glucose in the plasma and
episodic ketoacidosis. Additional symptoms of diabetes mellitus include
polydipsia, glucosuria, polyuria, lipemia and hunger (King et al., 1998; WCPD,
2012).
Diabetes
mellitus is a heterogeneous clinical disorder with numerous causes. Two main
classifications of diabetes mellitus exist, idiopathic and secondary.
Idiopathic diabetes is divided into Type 1 diabetes (IDDM) and Type 2 diabetes
(NIDDM) (WHO, 2003).
Type 2
diabetes is associated with a cluster of interrelated plasma lipid and
lipoprotein abnormalities, including reduced HDL cholesterol, a predominance of
small dense LDL particles, and elevated triglycerides. These abnormalities
occur in many patients despite normal LDL cholesterol levels. These changes are
also a feature of the insulin resistance syndrome (also known as the metabolic
syndrome), which underlies many cases of type 2 diabetes. In fact, pre-diabetic
individuals often exhibit an atherogenic pattern of risk factors that includes
higher levels of total cholesterol, LDL cholesterol, and triglycerides and
lower levels of HDL cholesterol than individuals who do not develop diabetes
(Krauss, 2004).
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